I am a sixth year graduate student focusing on understanding how the hypothalamus changes in brain aging and Alzheimer’s disease at single-cell resolution. I work with Prof. Ashley Webb at the Buck Institute for Research on Aging, previously at Brown University. I received my Bachelor’s degree in Biology from Zhiyuan Honor’s Program at SJTU, and Master’s degree in Data Science through Brown’s Open Graduate Education. I am currently supported by the NIH/NIA F99 fellowship.

Selected Publications

Machine Learning

  1. CellBiAge: Improved single-cell age classification using data binarization [Paper] [Code]
    Doudou Yu, Manlin Li, Guanjie Linghu, Yihuan Hu, Kaitlyn H Hajdarovic, An Wang, Ritambhara Singh, Ashley E Webb
    Cell reports 2023 Dec
    image

Hypothalamus

  1. Single-cell analysis of the aging female mouse hypothalamus [Paper] [Code]
    Kaitlyn H Hajdarovic, Doudou Yu, Lexi-Amber Hassell, Shane A Evans, Sarah Packer, Nicola Neretti, Ashley E Webb
    Nature Aging 2022 July
    image

  2. Understanding the aging hypothalamus, one cell at a time [Review]
    Kaitlyn H. Hajdarovic, Doudou Yu, Ashley E. Webb
    Trends in neurosciences 2022 Dec
    image

Reprogramming

  1. Reprogramming to recover youthful epigenetic information and restore vision [Paper]
    Yuancheng Lu, Benedikt Brommer, Xiao Tian, Anitha Krishnan, Margarita Meer, Chen Wang, Daniel L Vera, Qiurui Zeng, Doudou Yu, Michael S Bonkowski, Jae-Hyun Yang, Songlin Zhou, Emma M Hoffmann, Margarete M Karg, Michael B Schultz, Alice E Kane, Noah Davidsohn, Ekaterina Korobkina, Karolina Chwalek, Luis A Rajman, George M Church, Konrad Hochedlinger, Vadim N Gladyshev, Steve Horvath, Morgan E Levine, Meredith S Gregory-Ksander, Bruce R Ksander, Zhigang He, David A Sinclair
    Nature 2020 Dec